Clenbuterol
Clenbuterol’s effects on neuroinflammation, muscle hypertrophy, and mitochondrial activity appear potentially relevant to ALS disease pathology. Data in murine models of motor neurondisease as well as two small flawed clinical…
Case: D
Grade D: Subjective report(s) of benefit without validated diagnoses and/or benefits
N-Acetylcysteine
ALSUntangled #82: N-acetylcysteine While NAC has theoretical therapeutic promise in ALS due to its antioxidant properties and ability to modulate oxidative stress and restore mitochondrial function, several case studies failed…
ISRIB
ISR over-activation may play an important role in ALS pathogenesis, as supported by data from pre-clinical models and PALS. Several different ISR inhibitors have been tried in ALS models or…
Alpha Lipoic Acid
ALA has several plausible mechanisms for slowing ALS progression, including enhancing energy production, reducing oxidative stress as a potent antioxidant and anti inflammation. Preclinical studies demonstrated better motor function and…
Light Therapy
Light therapy has not yet been convincingly shown to help people with ALS. However, at specific wavelengths and energy densities, LT appears safe and has theoretically plausible mechanisms. There is…
Vinpocetine
Vinpocetine has several plausible mechanisms by which it could slow ALS progression. There are two PALS online who reported improved motor functions on supplement cocktails containing Vinpocetine, but many other…
Anti-fungals
It is unknown if fungi exist in the brain of PALS. If they do exist, it is unknown if they have any pathogenic effect, and unknown if antifungal drugs would…
Perampanel
Perampanel is a drug currently used to treat seizures which has a mechanism of action that theoretically could be useful in treating patients with ALS. A single flawed study in…