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Pre-clinical models (animal or cell models recognized by ALSUntangled reviewers to be relevant to ALS)

Glucocorticoid Corticosteroids

August 29, 2022

In conclusion, corticosteroids are a class of medications with wide ranging clinical uses and well studied effects on the immune system. ALS progression is associated with changes in immune system function, with the early disease states associated with anti inflammatory immune markers and the advanced disease states associated withpro inflammatory immune markers. Although treatment with […]

RT001

January 28, 2019

RT001 has a novel mechanism for reducing oxidative stress that could theoretically work better than more traditional antioxidants. In the small trial of patients with Friedreich’s ataxia, it seems to be safe and well-tolerated at lower dosages but can cause nausea and diarrhea at higher doses. At the time of this writing, there is very […]

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