Pyridostigmine
Pyridostigmine has a plausible mechanism for transiently enhancing neuromuscular transmission in early stage ALS, where NMJ transmission is impaired but motor neuron numbers are preserved. However, there is no plausible…
Trial: U
Grade U: No useful information was found for this category
ISRIB
ISR over-activation may play an important role in ALS pathogenesis, as supported by data from pre-clinical models and PALS. Several different ISR inhibitors have been tried in ALS models or…
Alpha Lipoic Acid
ALA has several plausible mechanisms for slowing ALS progression, including enhancing energy production, reducing oxidative stress as a potent antioxidant and anti inflammation. Preclinical studies demonstrated better motor function and…
Psilocybin
Psilocybin may be able to influence ALS relevant mechanisms including neuroinflammation and brain glutamate levels, but this ability has not yet been demonstrated in ALS models or in PALS.There have…
WAHLS Protocol
Because components of the Wahls diet may affect inflammation, oxidative stress and mitochondrial dysfunction, it has plausible mechanisms for slow-ing ALS. Although a cross sectional study suggests the intake of…
PoNS Device
Considering the fact that electrical stimulation was first used as a medical treatment more than 100 years ago (30), and first used as an ALS treatment 30 years ago (31),…
Ashwagandha
WS appears reasonably safe, has plausible mechanisms by which it might slow ALS progression, and has promising data obtained in multiple different clinical models of ALS. While there are also…
Lions Mane
While Lion’s Mane may have neuroprotective, neurotrophic, antioxidant, and anti inflammatory properties that could, at least in theory, potentially help ALS, there are still no studies in ALS relevant cell…