Psilocybin
Psilocybin may be able to influence ALS relevant mechanisms including neuroinflammation and brain glutamate levels, but this ability has not yet been demonstrated in ALS models or in PALS.There have been no studies of psilocybin in ALS relevant preclinical models, and no case reports documenting the effects of psilocybin on ALS progression. Given the potential […]
WAHLS Protocol
Because components of the Wahls diet may affect inflammation, oxidative stress and mitochondrial dysfunction, it has plausible mechanisms for slow-ing ALS. Although a cross sectional study suggests the intake of certain macro and micronutrients enriched in the Wahls diet was associated with better baseline motor function and lower risk for getting ALS, no case reports […]
PoNS Device
Considering the fact that electrical stimulation was first used as a medical treatment more than 100 years ago (30), and first used as an ALS treatment 30 years ago (31), it is disappointing that we have yet to find a clear way to use this to help PALS. PoNS™ is a newer version of this. […]
Insulin
Insulin treatment for ALS is an intriguing area for future research. However, the risks of insulin administration are significant and potentially lethal. Currently, there is no clinical evidence to support its use in PALS. Therefore, we cannot endorse insulin as a way to slow, stop, or reverse ALS progression at this time.
Proprionyl-L-Carnitine
There are good theoretical mechanisms for carnitines, some preclinical evidence for LC and ALCAR, and a single clinical trial that suggested ALCAR could slow disease progression in PALS. All three carnitines appear to be well tolerated, generally safe and inexpensive. We believe that there is a need for future clinical trials of carnitines in PALS […]
Antiretrovirals
Antiretrovirals are a group of diverse drugs developed for HIV infections that vary widely in theoretical efficacy against HERVs, side effect profiles, and cost. HERV expression is apparently increased in some PALS; however, it is unknown if this is abeneficial, neutral, or pathological process. Furthermore, it is not clear if ARV-targeted mechanisms such as cell […]
Basis
Basis has mechanisms of action that could theoretically be useful in treating ALS. It appeared reasonably safe in a small, short duration study of healthy volunteers and it is fairly inexpensive. However, we found no data in preclinical ALS models, no case reports, and no trials in PALS. Based on this lack of data, ALSUntangled […]
Sodium Chlorite NP001
The NP001 formulation of sodium chlorite acts through a plausible mechanism and preliminary data suggest that it is safe and may slow ALS progression in some PALS. The WF10 formulation of SC appears to act through this same mechanism. Although WF10 is available for off-label use, it is very expensive, may have more side-effects than […]