Clenbuterol
Clenbuterol’s effects on neuroinflammation, muscle hypertrophy, and mitochondrial activity appear potentially relevant to ALS disease pathology. Data in murine models of motor neurondisease as well as two small flawed clinical…
Mechanism: A
Grade A: Shown in a peer-reviewed publication to act on a relevant mechanism in humans
Alpha Lipoic Acid
ALA has several plausible mechanisms for slowing ALS progression, including enhancing energy production, reducing oxidative stress as a potent antioxidant and anti inflammation. Preclinical studies demonstrated better motor function and…
Caffeine
Caffeine is inexpensive, reasonably safe at doses of under 400 mg daily, and has plausible mechanisms by which it could slow ALS progression. However, data from pre-clinical models are contradictory…
Astaxanthin
There are theoretical mechanisms supporting the potential role of astaxanthin in the treatment of ALS, however, there are no ALS specific preclinical data exploring this treatment. One verified “ALS reversal”…
Ozone
Ozone therapy has possible mechanisms for treating ALS. A preclinical study in very small numbers of mTDP43 mice (which has yet to be peerreviewed) suggested benefits on motor function and…
Butyrates
Butyrates have plausible mechanisms for slowing ALS progression and positive pre clinical studies. One trial suggests that sodium phenylbutyrate (NaPB) in combination with Tauroursodeoxycholic acid (TUDCA) can slow ALS progression…
Melatonin
Melatonin has plausible mechanisms, some positive (and some negative) pre-clinical data, and two case reports in which it was part of a cocktail of treatments associated with recovery of lost…
Tamoxifen
Tamoxifen is reasonably safe, has plausible mechanisms for treating ALS, and has at least one positive preclinical study. One case report and 2 small human trials suggested an association between…